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ea0063gp159 | Cushing's | ECE2019

Skeletal muscle fatty infiltration in the thigh, as assessed by MRI T2-weighted and 3-point Dixon sequences, is associated with poor performance on muscle function testing in patients with Cushing’s syndrome in remission

Martel Luciana , Alonso Alicia , Bascunana Helena , Manera Jordi Diaz , Llauger Jaume , Nunez-Peralta Claudia , Biagetti Betina , Montesinos Paula , Webb Susan , Valassi Elena

Background: Muscle weakness may persist in patients with Cushings syndrome (CS) long-term after resolution of hypercortisolism, but mechanisms determining this sustained impairment are not known. We hypothesized that alteration of muscle structure, due to fatty infiltration, is associated with muscle dysfunctions in these patients.Patients & methods: Twenty-six CS women [mean(±S.D.) age 49±12 years; mean(±S....

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Skeletal muscle fatty infiltration in the thigh, as assessed by MRI T2-weighted and 3-point Dixon sequences, is associated with poor performance on muscle function testing in patients with Cushing’s syndrome in remission

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